Compound or practice · Supplement
Centrophenoxine
An old cholinergic anti-aging compound with dated cognitive-decline data.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Cognition (elderly)Evidence grade D
Dated
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Cognition (elderly) (grade D).
The evidence in words
What it is
Centrophenoxine is a DMAE-related cholinergic compound studied decades ago for aging and cognition.
How it works
It raises acetylcholine and helps clear lipofuscin (an aging pigment) in models.
What the evidence shows
Some old studies in dementia and age-related decline; little modern evidence, none convincing in healthy people. A relic with a following.
Safety & interactions
Generally tolerated.
Bottom line
An aging-brain compound with dated, weak evidence. Not established for healthy cognition.
Related reading
Entries that share this one's tags or conditions.
- Centrophenoxine for Cognition (elderly)Evidence grade D — DatedEvidence grade D
- Centrophenoxine: side effects, safety & interactionsGenerally tolerated.Evidence grade D
- DMAEA choline-adjacent compound for focus and skin with weak, mixed evidence.Evidence grade D
- AniracetamA fat-soluble racetam with an anxiety-and-mood reputation and mostly preclinical human backing.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.