Apigenin for Sleep / calm

Evidence grade C — Chamomile-level evidence

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade C — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Sleep / calmChamomile-level evidence	Evidence grade C	Small	low

Read off the same rows as above. Nothing here is added that the entry does not itself record.

For sleep / calm, Apigenin earns evidence grade C (small effect, low consistency) — the evidence is limited or mixed. Chamomile-level evidence

It appears to bind benzodiazepine sites on GABA-A receptors weakly, producing gentle anxiolytic/sedative effects, and has antioxidant activity.

50 mg near bedtime, or simply chamomile tea.

Benign at these doses; theoretical mild CYP interactions at high intakes.

A pleasant, low-risk wind-down aid with more tradition than trials. Chamomile tea gets you most of the way.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Entries that share this one's tags or conditions.

Apigenin: dosage and how to take it50 mg near bedtime, or chamomile tea.Evidence grade C
Apigenin: side effects, safety & interactionsBenign at these doses; theoretical mild CYP interactions at high intakes.Evidence grade C
Passionflower for AnxietyEvidence grade C — Small trialsEvidence grade C
Passionflower for Sleep qualityEvidence grade C — ModestEvidence grade C

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.