Compound or practice · Sleep
Apigenin
The chamomile flavone behind the bedtime-tea calm — mild, benign, thinly studied as an isolated supplement.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Sleep / calmEvidence grade C
Chamomile-level evidence
Smalllow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Sleep / calm (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
GlycineWorks together
Two gentle, non-sedating onset levers.
The evidence in words
What it is
Apigenin is a flavonoid abundant in chamomile, popularized as an isolated sleep-and-calm supplement.
How it works
It appears to bind benzodiazepine sites on GABA-A receptors weakly, producing gentle anxiolytic/sedative effects, and has antioxidant activity.
What the evidence shows
Direct human trials of isolated apigenin for sleep are scarce; chamomile (which contains it) has modest anxiolytic and sleep-quality data. Reasonable as a gentle wind-down aid, essentially unproven as an isolate.
How to use it
50 mg near bedtime, or simply chamomile tea.
Safety & interactions
Benign at these doses; theoretical mild CYP interactions at high intakes. Glycine — Two gentle, non-sedating onset levers.
Bottom line
A pleasant, low-risk wind-down aid with more tradition than trials. Chamomile tea gets you most of the way.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 50 mg near bedtime, or chamomile tea.
Goes with
- GlycineTwo gentle, non-sedating onset levers.Evidence grade B
Related reading
Entries that share this one's tags or conditions.
- Apigenin for Sleep / calmEvidence grade C — Chamomile-level evidenceEvidence grade C
- Apigenin: dosage and how to take it50 mg near bedtime, or chamomile tea.Evidence grade C
- Apigenin: side effects, safety & interactionsBenign at these doses; theoretical mild CYP interactions at high intakes.Evidence grade C
- L-Tryptophan / 5-HTPSerotonin/melatonin precursors with modest sleep-and-mood signals — and the sharpest serotonergic-drug caution on the shelf.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.