Outcome map · Supplement
LDL cholesterol: what the evidence supports
11 graded interventions for ldl cholesterol, ranked by strength of evidence.
- Overall grade
- Grade A
- Last revised
- 11
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
3 at grade A · 2 at grade B · 4 at grade C · 2 at grade D — 11 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Psyllium HuskEvidence grade A
Bile-acid binding
Smallhigh
- Red Yeast RiceEvidence grade A
Contains a statin
Moderatehigh
- Plant Sterols / StanolsEvidence grade A
~8–10% at 2 g/day
Moderatehigh
- GlucomannanEvidence grade B
Bile-acid binding
Smallhigh
- Beta-SitosterolEvidence grade B
Sterol effect
Smallhigh
- GarlicEvidence grade C
Minor
Smallmixed
- Artichoke Leaf ExtractEvidence grade C
Modest
Smallmixed
- TocotrienolsEvidence grade C
Dose-sensitive
Smallmixed
- Black Seed Oil (Nigella sativa)Evidence grade C
Modest
Smallmixed
- GuggulEvidence grade D
No benefit; some worsening
Triviallow
- PolicosanolEvidence grade D
Failed to replicate
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Garlic (grade C); Artichoke Leaf Extract (grade C); Tocotrienols (grade C); Black Seed Oil (Nigella sativa) (grade C); Guggul (grade D); Policosanol (grade D).
The evidence in words
The evidence map
This is the ranked evidence for ldl cholesterol: every compound in the knowledge base with a graded effect, best-supported first. Grades reflect replication and effect size, not popularity or marketing.
Best-supported
Psyllium Husk (grade A) — Bile-acid binding · Red Yeast Rice (grade A) — Contains a statin · Plant Sterols / Stanols (grade A) — ~8–10% at 2 g/day · Glucomannan (grade B) — Bile-acid binding · Beta-Sitosterol (grade B) — Sterol effect
Weaker or unproven
Garlic (grade C) — Minor · Artichoke Leaf Extract (grade C) — Modest · Tocotrienols (grade C) — Dose-sensitive · Black Seed Oil (Nigella sativa) (grade C) — Modest · Guggul (grade D) — No benefit; some worsening · Policosanol (grade D) — Failed to replicate
Goes with
- Psyllium HuskGrade AEvidence grade A
- Red Yeast RiceGrade AEvidence grade B
- Plant Sterols / StanolsGrade AEvidence grade A
- GlucomannanGrade BEvidence grade B
- Beta-SitosterolGrade BEvidence grade B
- GarlicGrade CEvidence grade B
- Artichoke Leaf ExtractGrade CEvidence grade C
- TocotrienolsGrade CEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Allergic rhinitis: what the evidence supports3 graded interventions for allergic rhinitis, ranked by strength of evidence.Evidence grade B
- Antibiotic-associated diarrhea: what the evidence supports2 graded interventions for antibiotic-associated diarrhea, ranked by strength of evidence.Evidence grade B
- Anxiety: what the evidence supports6 graded interventions for anxiety, ranked by strength of evidence.Evidence grade B
- Benign prostatic hyperplasia: what the evidence supports3 graded interventions for benign prostatic hyperplasia, ranked by strength of evidence.Evidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.