Compound or practice · Supplement
Glucomannan
A viscous konjac fiber that genuinely blunts appetite and LDL — the rare fat-loss supplement with real (modest) support.
- Overall grade
- Grade B
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
2 at grade B — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Weight (appetite)Evidence grade B
Pre-meal, with water
Smallmixed
- LDL cholesterolEvidence grade B
Bile-acid binding
Smallhigh
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Weight (appetite) (mixed agreement).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
LevothyroxineMind the timing
Viscous fiber binds medications — separate by hours.
The evidence in words
What it is
Glucomannan is a highly viscous soluble fiber from konjac root, used for satiety, weight, and cholesterol.
How it works
It absorbs water into a thick gel that slows gastric emptying and promotes fullness, and binds bile acids to lower LDL.
What the evidence shows
Reasonable evidence for modest weight loss (via appetite) and LDL reduction when taken before meals with water; effects are small but real, and it's an EU-authorized weight claim. A genuine, if unglamorous, option.
Safety & interactions
Must be taken with ample water (choking/obstruction risk otherwise); can bind medications — separate them. levothyroxine — Viscous fiber binds medications — separate by hours.
Bottom line
One of the few weight supplements that isn't nonsense: a viscous fiber that curbs appetite and lowers LDL. Take before meals with plenty of water, apart from your pills.
Related reading
Entries that share this one's tags or conditions.
- Glucomannan for LDL cholesterolEvidence grade B — Bile-acid bindingEvidence grade B
- Glucomannan for Weight (appetite)Evidence grade B — Pre-meal, with waterEvidence grade B
- Glucomannan: side effects, safety & interactionsMust be taken with ample water (choking/obstruction risk otherwise); can bind medications — separate them.Evidence grade B
- Beta-GlucansTwo different molecules under one name: oat beta-glucan reliably lowers LDL; yeast/mushroom beta-glucan modulates immunity.Evidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.