Compound or practice · Supplement
Tocotrienols
The other half of the vitamin E family, studied for lipids and liver — promising, not settled, and antagonized by alpha-tocopherol.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
2 at grade C — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- LDL cholesterolEvidence grade C
Dose-sensitive
Smallmixed
- Fatty liverEvidence grade C
Early
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: LDL cholesterol (grade C); Fatty liver (grade C).
The evidence in words
What it is
Tocotrienols are the less-common form of vitamin E (vs tocopherols), studied for cholesterol, liver, and bone.
How it works
They inhibit cholesterol synthesis and have distinct antioxidant and anti-inflammatory actions.
What the evidence shows
Some trials show LDL and fatty-liver improvements and possible bone/neuro effects; results are mixed and dose-sensitive. Notably, co-taking high alpha-tocopherol can blunt tocotrienol benefits.
Safety & interactions
Generally safe; mild antiplatelet effect at high doses.
Bottom line
A distinct vitamin-E fraction with promising lipid/liver signals. Take apart from high-dose alpha-tocopherol; evidence still maturing.
Related reading
Entries that share this one's tags or conditions.
- Tocotrienols for Fatty liverEvidence grade C — EarlyEvidence grade C
- Tocotrienols for LDL cholesterolEvidence grade C — Dose-sensitiveEvidence grade C
- Tocotrienols: side effects, safety & interactionsGenerally safe; mild antiplatelet effect at high doses.Evidence grade C
- CholineAn essential nutrient most people under-eat — critical in pregnancy for fetal brain development.Evidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.