Hypertension: what the evidence supports

8 graded interventions for hypertension, ranked by strength of evidence.

Overall grade: Grade B
Last revised: Jul 10, 2026; 8
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

5 at grade B · 3 at grade C — 8 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
MagnesiumSmall additive lowering	Evidence grade B	Unclear	mixed
PotassiumVia sodium-potassium balance	Evidence grade B	Unclear	mixed
GarlicModest additive lowering	Evidence grade B	Unclear	mixed
Cocoa FlavanolsModest	Evidence grade B	Unclear	mixed
HibiscusFood-based	Evidence grade B	Unclear	mixed
Olive Leaf ExtractModest	Evidence grade C	Unclear	mixed
Grape Seed ExtractModest	Evidence grade C	Unclear	mixed
NattokinaseModest	Evidence grade C	Unclear	mixed

MagnesiumEvidence grade B
Small additive lowering
Unclearmixed
PotassiumEvidence grade B
Via sodium-potassium balance
Unclearmixed
GarlicEvidence grade B
Modest additive lowering
Unclearmixed
Cocoa FlavanolsEvidence grade B
Modest
Unclearmixed
HibiscusEvidence grade B
Food-based
Unclearmixed
Olive Leaf ExtractEvidence grade C
Modest
Unclearmixed
Grape Seed ExtractEvidence grade C
Modest
Unclearmixed
NattokinaseEvidence grade C
Modest
Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Olive Leaf Extract (grade C); Grape Seed Extract (grade C); Nattokinase (grade C).
Studies disagree: Magnesium (mixed agreement); Potassium (mixed agreement); Garlic (mixed agreement); Cocoa Flavanols (mixed agreement); Hibiscus (mixed agreement).

The evidence in words

The evidence map

This is the ranked evidence for hypertension: every compound in the knowledge base with a graded effect, best-supported first. Grades reflect replication and effect size, not popularity or marketing.

Best-supported

Magnesium (grade B) — Small additive lowering · Potassium (grade B) — Via sodium-potassium balance · Garlic (grade B) — Modest additive lowering · Cocoa Flavanols (grade B) — Modest · Hibiscus (grade B) — Food-based

Weaker or unproven

Olive Leaf Extract (grade C) — Modest · Grape Seed Extract (grade C) — Modest · Nattokinase (grade C) — Modest

Goes with

MagnesiumGrade BEvidence grade B
PotassiumGrade BEvidence grade B
GarlicGrade BEvidence grade B
Cocoa FlavanolsGrade BEvidence grade B
HibiscusGrade BEvidence grade B
Olive Leaf ExtractGrade CEvidence grade C
Grape Seed ExtractGrade CEvidence grade C
NattokinaseGrade CEvidence grade C

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Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.