Compound or practice · Supplement
Nattokinase
A fermented-soy enzyme with fibrinolytic activity and modest blood-pressure data — real mechanism, a bleeding caution.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
3 at grade C — 3 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Blood pressureEvidence grade C
Modest
Smallmixed
- Fibrinolytic markersEvidence grade C
Real activity
Moderatemixed
Conditions
How the entry reads its effect on diagnosed conditions: the direction first, then the grade. Never a substitute for the person who treats you.
- Hypertension May improveEvidence grade CModestGrade C
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Blood pressure (grade C); Fibrinolytic markers (grade C).
- Caution with Anticoagulants (warfarin): Fibrinolytic — additive bleeding risk with anticoagulants.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Anticoagulants (warfarin)Caution
Fibrinolytic — additive bleeding risk with anticoagulants.
The evidence in words
What it is
Nattokinase is an enzyme from natto (fermented soybeans) with clot-dissolving (fibrinolytic) activity.
How it works
It breaks down fibrin and may reduce blood viscosity and blood pressure.
What the evidence shows
Small trials show modest blood-pressure reduction and improved fibrinolytic markers; hard cardiovascular-outcome data are lacking. The fibrinolytic action is real, which is exactly why it carries a bleeding-interaction caution.
How to use it
2,000 FU/day if used.
Safety & interactions
Additive bleeding risk with anticoagulants/antiplatelets and around surgery; soy-allergy caution. warfarin — Fibrinolytic — additive bleeding risk with anticoagulants.
Bottom line
A real fibrinolytic enzyme with modest blood-pressure data. Don't combine with blood thinners or use around surgery.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 2,000 FU/day.
Related reading
Entries that share this one's tags or conditions.
- Nattokinase for Blood pressureEvidence grade C — ModestEvidence grade C
- Cocoa FlavanolsThe flavanols in cocoa genuinely improve blood-vessel function and modestly lower blood pressure — the sugar is the catch.Evidence grade B
- HibiscusHibiscus tea reliably lowers blood pressure a few points — one of the better food-based options.Evidence grade B
- Cocoa Flavanols for Blood pressureEvidence grade B — Modest reductionEvidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.