Compound or practice · Supplement
Grape Seed Extract
A procyanidin extract with modest blood-pressure and edema data.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
3 at grade C — 3 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Blood pressureEvidence grade C
Modest
Smallmixed
- Venous edemaEvidence grade C
Symptom relief
Smallmixed
Conditions
How the entry reads its effect on diagnosed conditions: the direction first, then the grade. Never a substitute for the person who treats you.
- Hypertension May improveEvidence grade CModestGrade C
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Blood pressure (grade C); Venous edema (grade C).
- Caution with Anticoagulants (warfarin): Mild antiplatelet — additive bleeding risk.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Anticoagulants (warfarin)Caution
Mild antiplatelet — additive bleeding risk.
The evidence in words
What it is
Grape seed extract is rich in proanthocyanidins, used for blood pressure, circulation, and antioxidant support.
How it works
Antioxidant and endothelial-supporting effects improving vascular tone and capillary integrity.
What the evidence shows
Meta-analyses show a modest blood-pressure reduction, particularly in younger or metabolic-syndrome patients, plus some benefit for leg edema/venous symptoms. Effects are small but consistent in direction.
How to use it
150–300 mg/day standardized.
Safety & interactions
Generally safe; mild antiplatelet action. warfarin — Mild antiplatelet — additive bleeding risk.
Bottom line
A modest, low-risk blood-pressure and circulation option. Reasonable adjunct.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 150–300 mg/day standardized.
Related reading
Entries that share this one's tags or conditions.
- Grape Seed Extract for Blood pressureEvidence grade C — ModestEvidence grade C
- Pycnogenol (Pine Bark)A pine-bark polyphenol with broad small-trial signals for circulation, blood pressure, and skin — much of it single-source.Evidence grade C
- Pycnogenol (Pine Bark) for Blood pressureEvidence grade C — ModestEvidence grade C
- Grape Seed Extract for HypertensionEvidence grade C — ModestEvidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.