Pycnogenol (Pine Bark) for Blood pressure

Evidence grade C — Modest

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade C — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Blood pressureModest	Evidence grade C	Small	mixed

Read off the same rows as above. Nothing here is added that the entry does not itself record.

For blood pressure, Pycnogenol (Pine Bark) earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Modest

Antioxidant and nitric-oxide-supporting actions improving microcirculation and endothelial function.

100–200 mg/day standardized.

Generally safe; mild antiplatelet action; additive blood-pressure lowering.

Broad but largely single-source evidence for circulation and skin. Plausible and low-risk; weigh the industry-funding caveat.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Pycnogenol (Pine Bark)Read the full Pycnogenol (Pine Bark) monographEvidence grade C

Entries that share this one's tags or conditions.

Grape Seed Extract for Blood pressureEvidence grade C — ModestEvidence grade C
Pycnogenol (Pine Bark) for Skin elasticity/UVEvidence grade C — Small trialsEvidence grade C
Pycnogenol (Pine Bark) for Venous insufficiencyEvidence grade C — Symptom reliefEvidence grade C
Grape Seed Extract for HypertensionEvidence grade C — ModestEvidence grade C

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.