Safety · Supplement
Vitamin B6: side effects, safety & interactions
Safe at low doses; chronic megadosing causes peripheral neuropathy that resolves slowly on stopping. Respect the upper l
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Safe at low doses; chronic megadosing causes peripheral neuropathy that resolves slowly on stopping. Respect the upper limit.
Interactions to respect
No major interactions are on record for Vitamin B6 at typical doses, but tell your clinician about everything you take.
What Vitamin B6 is
B6 is a water-soluble vitamin whose active form, pyridoxal-5-phosphate (P5P), is a cofactor for over a hundred enzymes, especially those handling amino acids and neurotransmitters. Frank deficiency is uncommon but subclinical low status occurs.
The honest bottom line
Useful and cheap for pregnancy nausea and PMS at modest doses, and a homocysteine cofactor — but this is the water-soluble vitamin to not megadose, because sustained high intakes damage sensory nerves.
Related reading
Entries that share this one's tags or conditions.
- Choline: side effects, safety & interactionsHigh doses cause fishy odor and GI effects; very high intakes may raise TMAO.Evidence grade B
- Folate (B9): side effects, safety & interactionsSafe at typical doses. The main caution is masking B12 deficiency (see B12). Very high folic-acid intakes and unmetaboliEvidence grade A
- Iodine: side effects, safety & interactionsHigh doses can induce thyroid dysfunction; kelp supplements deliver erratic, sometimes excessive amounts. Stay near requEvidence grade B
- Vitamin B6A cofactor for neurotransmitter and amino-acid metabolism; genuinely useful for pregnancy nausea and PMS, toxic if chronically megadosed.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.