Safety · Supplement
Methylene Blue: side effects, safety & interactions
Turns urine blue-green. Dangerous serotonin-syndrome risk with serotonergic medications. Avoid in G6PD deficiency (hemol
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Turns urine blue-green. Dangerous serotonin-syndrome risk with serotonergic medications. Avoid in G6PD deficiency (hemolysis) and pregnancy. Dose precision matters — pharmaceutical-grade only.
Interactions to respect
SSRIs / SNRIs — MAO inhibition + serotonergic drugs = serotonin-syndrome risk. Do not combine. · MAOIs — Additive MAO inhibition.
What Methylene Blue is
Methylene blue is a synthetic dye used medically (for methemoglobinemia) and, at low doses, promoted for cognition and energy.
The honest bottom line
Legitimate mitochondrial pharmacology with early cognitive signals, but MAOI-level interactions make it inappropriate to stack casually — especially with any serotonergic drug.
Related reading
Entries that share this one's tags or conditions.
- Methylene BlueA century-old dye and drug repurposed as a low-dose mitochondrial nootropic — real pharmacology, serious MAOI-level interactions.Evidence grade C
- Acetyl-L-Carnitine (ALCAR): side effects, safety & interactionsGenerally safe; can cause GI upset, and, like carnitine, may raise TMAO. Mildly stimulating for some — take earlier in tEvidence grade B
- Idebenone: side effects, safety & interactionsGenerally tolerated; medical uses are supervised.Evidence grade C
- Methylene Blue for Memory / brain metabolismEvidence grade C — Low-dose, small trialsEvidence grade C
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.