Evidence brief · Supplement
Methylene Blue for Memory / brain metabolism
Evidence grade C — Low-dose, small trials
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Memory / brain metabolismEvidence grade C
Low-dose, small trials
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Memory / brain metabolism (grade C).
The evidence in words
The verdict
For memory / brain metabolism, Methylene Blue earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Low-dose, small trials
How it might work
At low doses it acts as an alternative electron carrier in mitochondria, supporting ATP production and acting as an antioxidant; it also inhibits monoamine oxidase (MAO).
How to use it
Safety & cautions
Turns urine blue-green. Dangerous serotonin-syndrome risk with serotonergic medications. Avoid in G6PD deficiency (hemolysis) and pregnancy. Dose precision matters — pharmaceutical-grade only.
Bottom line
Legitimate mitochondrial pharmacology with early cognitive signals, but MAOI-level interactions make it inappropriate to stack casually — especially with any serotonergic drug.
Goes with
- Methylene BlueRead the full Methylene Blue monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Methylene Blue: side effects, safety & interactionsTurns urine blue-green. Dangerous serotonin-syndrome risk with serotonergic medications. Avoid in G6PD deficiency (hemolEvidence grade C
- Noopept for CognitionEvidence grade D — Limited Western dataEvidence grade D
- Oxiracetam for CognitionEvidence grade D — SparseEvidence grade D
- Acetyl-L-Carnitine (ALCAR)The brain-penetrant carnitine — real evidence for diabetic neuropathy, softer signals for mood and aging cognition.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.