Safety · Supplement

Kratom (Mitragyna speciosa): side effects, safety & interactions

Dependence and withdrawal occur; risks rise with high doses, other depressants (alcohol, benzodiazepines) and adulterate

Overall grade: Grade D
Last revised: Jul 10, 2026; 0
graded outcomes: 0
references listed

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Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

The evidence in words

Safety profile

Dependence and withdrawal occur; risks rise with high doses, other depressants (alcohol, benzodiazepines) and adulterated products. Liver-injury case reports exist. Legality varies by region.

Interactions to respect

Sedative — Dangerous additive CNS/respiratory depression with alcohol, benzodiazepines, opioids.

What Kratom (Mitragyna speciosa) is

Kratom is a Southeast Asian tree whose leaves contain mitragynine; low doses stimulate, higher doses are opioid-like.

The honest bottom line

Pharmacologically real but genuinely risky and habit-forming — not a casual supplement. If used to manage opioid problems, that belongs in a clinical setting, not self-treatment.

Entries that share this one's tags or conditions.

Kratom (Mitragyna speciosa)A partial-opioid leaf used for pain, energy and opioid-withdrawal self-treatment — real effects, real dependence and safety risks.Evidence grade D
Kratom (Mitragyna speciosa) for Pain / opioid withdrawalEvidence grade D — Observational onlyEvidence grade D
Beta-Carotene: side effects, safety & interactionsFood amounts are safe (excess just yellows skin). High-dose supplements are contraindicated in smokers and asbestos-expoEvidence grade C
BPC-157: side effects, safety & interactionsNo human safety data; sourced from unregulated suppliers with purity/contamination risk. Not an approved drug.Evidence grade D

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.