Evidence brief · Supplement
Kratom (Mitragyna speciosa) for Pain / opioid withdrawal
Evidence grade D — Observational only
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Pain / opioid withdrawalEvidence grade D
Observational only
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Pain / opioid withdrawal (grade D).
The evidence in words
The verdict
For pain / opioid withdrawal, Kratom (Mitragyna speciosa) earns evidence grade D (unclear effect, low consistency) — the evidence does not support the claim. Observational only
How it might work
Its alkaloids are partial agonists at mu-opioid receptors (with less respiratory depression than classical opioids) plus adrenergic effects at low doses.
How to use it
Safety & cautions
Dependence and withdrawal occur; risks rise with high doses, other depressants (alcohol, benzodiazepines) and adulterated products. Liver-injury case reports exist. Legality varies by region.
Bottom line
Pharmacologically real but genuinely risky and habit-forming — not a casual supplement. If used to manage opioid problems, that belongs in a clinical setting, not self-treatment.
Goes with
- Kratom (Mitragyna speciosa)Read the full Kratom (Mitragyna speciosa) monographEvidence grade D
Related reading
Entries that share this one's tags or conditions.
- Kratom (Mitragyna speciosa): side effects, safety & interactionsDependence and withdrawal occur; risks rise with high doses, other depressants (alcohol, benzodiazepines) and adulterateEvidence grade D
- Beta-Carotene for Lung cancer (smokers, high-dose)Evidence grade B — Increased riskEvidence grade B
- Beta-Carotene for Vitamin-A statusEvidence grade B — Corrects deficiencyEvidence grade B
- BPC-157 for Tissue / injury healingEvidence grade D — Animal-onlyEvidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.