Safety · Supplement
Ergothioneine: side effects, safety & interactions
Appears very safe; naturally consumed in mushrooms.
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Appears very safe; naturally consumed in mushrooms.
Interactions to respect
No major interactions are on record for Ergothioneine at typical doses, but tell your clinician about everything you take.
What Ergothioneine is
Ergothioneine is a unique amino-acid antioxidant concentrated in mushrooms; humans have a specific transporter (OCTN1) that retains it in tissues.
The honest bottom line
A biologically special antioxidant with intriguing longevity associations, awaiting outcome trials. Eating mushrooms is the easy, evidence-adjacent way to get it.
Related reading
Entries that share this one's tags or conditions.
- Chaga: side effects, safety & interactionsOxalate load — kidney-stone/injury risk; caution with anticoagulants and diabetes drugs.Evidence grade D
- Sulforaphane: side effects, safety & interactionsGenerally safe; GI upset at high doses.Evidence grade C
- AHCC: side effects, safety & interactionsGenerally well tolerated; mild GI effects. As an immune stimulant, caution with immunosuppressants/autoimmunity.Evidence grade C
- Alpha-Lipoic Acid: side effects, safety & interactionsGenerally safe; can lower glucose (watch for lows with diabetes meds) and rarely triggers an insulin-autoimmune reactionEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.