Compound or practice · Supplement
Resveratrol
The 'red wine molecule' that launched the sirtuin craze — and then failed to reproduce its promise in humans.
- Overall grade
- Grade D
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
2 at grade D — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Metabolic markersEvidence grade D
Inconsistent
Triviallow
- Longevity / healthspanEvidence grade D
No human evidence
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Metabolic markers (grade D); Longevity / healthspan (grade D).
- Caution with Anticoagulants (warfarin): Mild antiplatelet effect — additive bleeding risk.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Anticoagulants (warfarin)Caution
Mild antiplatelet effect — additive bleeding risk.
The evidence in words
What it is
Resveratrol is a polyphenol from grapes and Japanese knotweed, famous for activating sirtuin longevity pathways in yeast and mice.
How it works
It was proposed to activate SIRT1 and mimic caloric restriction; in humans the effects are small, inconsistent, and complicated by poor bioavailability.
What the evidence shows
Despite enormous hype, human trials show at most trivial and inconsistent effects on metabolic and cardiovascular markers, and it can blunt some exercise adaptations. The animal-to-human translation simply did not hold. Safe but underwhelming.
How to use it
150–500 mg/day if trialing; expectations should be low.
Safety & interactions
Generally safe; mild antiplatelet effect and possible estrogenic activity at high doses. warfarin — Mild antiplatelet effect — additive bleeding risk.
Bottom line
The compound that started the longevity-supplement era and then disappointed. Human data are weak; spend elsewhere.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- If trialing
- 150–500 mg/day.
Related reading
Entries that share this one's tags or conditions.
- PQQA 'mitochondrial biogenesis' supplement whose small human trials are unconvincing.Evidence grade D
- Resveratrol for Longevity / healthspanEvidence grade D — No human evidenceEvidence grade D
- Resveratrol for Metabolic markersEvidence grade D — InconsistentEvidence grade D
- Resveratrol: dosage and how to take it150–500 mg/day.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.