Compound or practice · Supplement
PQQ
A 'mitochondrial biogenesis' supplement whose small human trials are unconvincing.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Fatigue / cognitionEvidence grade D
Weak, small studies
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Fatigue / cognition (grade D).
The evidence in words
What it is
PQQ is a redox cofactor marketed for mitochondrial biogenesis and cognition.
How it works
Proposed to stimulate the growth of new mitochondria and act as an antioxidant.
What the evidence shows
A handful of small studies report changes in fatigue, sleep, or inflammatory markers, but the evidence is thin, heterogeneous, and often industry-linked. Not established.
How to use it
10–20 mg/day if trialing.
Safety & interactions
Appears safe at these doses.
Bottom line
Thin evidence for a lot of marketing. Not a priority.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- If trialing
- 10–20 mg/day.
Related reading
Entries that share this one's tags or conditions.
- Nicotinamide RibosideThe better-studied NAD+ precursor — reliably raises NAD+, still short on hard human outcomes.Evidence grade C
- NMNAn NAD+ precursor with real biomarker effects (NAD+ rises) and no proven clinical or longevity outcomes yet.Evidence grade C
- PQQ for Fatigue / cognitionEvidence grade D — Weak, small studiesEvidence grade D
- PQQ: dosage and how to take it10–20 mg/day.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.