Medication · Medication
MAOIs
Monoamine oxidase inhibitors — older, powerful antidepressants with the strictest interaction profile in psychiatry.
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A medication reference built from the interaction graph. It is not prescribing information — the label and your prescriber are.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Caution with Yohimbine: Hypertensive-crisis risk — do not combine.
- Caution with Methylene Blue: Additive MAO inhibition.
- Caution with L-Tryptophan / 5-HTP: Serotonin precursor plus an MAOI risks serotonin syndrome — contraindicated.
- Caution with L-Tyrosine: Catecholamine precursor on an MAOI risks a hypertensive reaction.
- Caution with Saffron: Serotonergic herb plus MAOI — additive serotonin risk.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
YohimbineCaution
Hypertensive-crisis risk — do not combine.
Methylene BlueCaution
Additive MAO inhibition.
L-Tryptophan / 5-HTPCaution
Serotonin precursor plus an MAOI risks serotonin syndrome — contraindicated.
L-TyrosineCaution
Catecholamine precursor on an MAOI risks a hypertensive reaction.
SaffronCaution
Serotonergic herb plus MAOI — additive serotonin risk.
The evidence in words
What it is
Monoamine oxidase inhibitors — older, powerful antidepressants with the strictest interaction profile in psychiatry.
How it works
They block the enzyme that breaks down serotonin, dopamine, and norepinephrine, so precursors and tyramine can accumulate to dangerous levels.
What it's used for
Treatment-resistant and atypical depression; selegiline also in Parkinson's.
Supplement & drug interactions
MAOIs has 5 documented interactions mapped below and in the interactions graph. The most interaction-sensitive drug class here. Amino-acid precursors (tyrosine, tryptophan, 5-HTP) risk hypertensive or serotonergic crises, and dietary tyramine is a classic trigger. Change nothing in a stack without the prescriber.
The rule
This is a medication reference for spotting interactions, not dosing advice. Every change to a supplement stack around a prescription belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- SSRIs & SNRIsSelective serotonin (and serotonin-norepinephrine) reuptake inhibitors — first-line drugs for depression and anxiety.Evidence grade A
- ADHD StimulantsPrescription stimulants for attention-deficit/hyperactivity disorder.Evidence grade A
- AlcoholEthanol — a CNS depressant and hepatotoxin with a broad interaction footprint.Evidence grade A
- AntibioticsDrugs that kill or stop bacteria — short courses with long gut shadows.Evidence grade A
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.