Interaction · Supplement
Melatonin + SSRIs / SNRIs: use with caution
Some SSRIs (fluvoxamine) spike melatonin levels — microdose or skip.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Watch with Melatonin: About Melatonin
The evidence in words
The interaction
Melatonin and SSRIs / SNRIs — a caution interaction. Some SSRIs (fluvoxamine) spike melatonin levels — microdose or skip.
What to do
Do not combine these casually. The interaction can matter clinically — bring it to the prescriber who manages the medication before stacking them.
About Melatonin
Melatonin is the hormone the pineal gland releases in darkness to signal biological night. Supplements shift the body clock and modestly aid sleep onset.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Kanna (Sceletium tortuosum) + SSRIs / SNRIs: use with cautionSSRI-like reuptake inhibition — serotonin-syndrome risk; don't combine.Evidence grade B
- L-Tryptophan / 5-HTP + SSRIs / SNRIs: use with cautionSerotonin-syndrome risk — do not combine without a prescriber.Evidence grade B
- Melatonin + Benzodiazepines: use with cautionAdditive sedation; time carefully and expect stronger next-morning grog.Evidence grade B
- Methylene Blue + SSRIs / SNRIs: use with cautionMAO inhibition + serotonergic drugs = serotonin-syndrome risk. Do not combine.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.