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Immunosuppressants

Drugs that suppress the immune system to prevent transplant rejection or control autoimmunity.

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A medication reference built from the interaction graph. It is not prescribing information — the label and your prescriber are.

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

  • Caution with Cat's Claw: Immune modulation may oppose the drug.
  • Caution with Grapefruit: Grapefruit sharply raises cyclosporine/tacrolimus levels — a classic dangerous food-drug interaction.
  • Caution with St. John's Wort: St John's Wort induces CYP3A4, lowering cyclosporine and risking transplant rejection.
  • Caution with Quercetin: Quercetin inhibits CYP3A4, potentially raising cyclosporine levels.
  • Caution with Berberine: Berberine inhibits CYP3A4/P-gp, raising cyclosporine/tacrolimus levels.

Interactions

Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.

  • Cat's ClawCaution

    Immune modulation may oppose the drug.

  • GrapefruitCaution

    Grapefruit sharply raises cyclosporine/tacrolimus levels — a classic dangerous food-drug interaction.

  • St. John's WortCaution

    St John's Wort induces CYP3A4, lowering cyclosporine and risking transplant rejection.

  • QuercetinCaution

    Quercetin inhibits CYP3A4, potentially raising cyclosporine levels.

  • BerberineCaution

    Berberine inhibits CYP3A4/P-gp, raising cyclosporine/tacrolimus levels.

The evidence in words

What it is

Drugs that suppress the immune system to prevent transplant rejection or control autoimmunity.

How it works

Many are metabolized by CYP3A4, so anything that inhibits or induces that enzyme swings their levels — with rejection or toxicity as the stakes.

What it's used for

Organ-transplant maintenance, severe autoimmune disease.

Supplement & drug interactions

Immunosuppressants has 5 documented interactions mapped below and in the interactions graph. The highest-stakes interactions here: grapefruit, berberine, and quercetin can raise cyclosporine/tacrolimus levels (toxicity), while St John's Wort lowers them (rejection). Immune-stimulating herbs (echinacea) oppose the drug's purpose. Nothing without the transplant team.

The rule

This is a medication reference for spotting interactions, not dosing advice. Every change to a supplement stack around a prescription belongs with the person who prescribes it.

Related reading

Entries that share this one's tags or conditions.

  • CorticosteroidsPotent anti-inflammatory and immunosuppressant steroids.Evidence grade A
  • GrapefruitNot a drug — a food, but a potent and long-lasting inhibitor of the CYP3A4 enzyme in the gut, which is why it has a drug-like interaction profile.Evidence grade A
  • Oral ContraceptivesEstrogen/progestin (or progestin-only) pills for contraception and cycle control.Evidence grade A
  • ADHD StimulantsPrescription stimulants for attention-deficit/hyperactivity disorder.Evidence grade A

Sources

This entry lists no references of its own.

Last revised . A grade is this entry's reading of the evidence, not medical advice.