Compound or practice · Supplement
Hyaluronic Acid (Oral)
An oral skin-and-joint supplement with modest hydration and knee-comfort signals.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
3 at grade C — 3 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Skin hydrationEvidence grade C
Small trials
Smallmixed
- Knee osteoarthritis comfortEvidence grade C
Modest
Smallmixed
Conditions
How the entry reads its effect on diagnosed conditions: the direction first, then the grade. Never a substitute for the person who treats you.
- Osteoarthritis May improveEvidence grade CKnee comfortGrade C
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Skin hydration (grade C); Knee osteoarthritis comfort (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Collagen PeptidesWorks together
Common skin/joint stack.
The evidence in words
What it is
Hyaluronic acid is a glycosaminoglycan in skin and joints; oral supplements are used for skin hydration and knee osteoarthritis.
How it works
Oral HA may be absorbed as fragments that signal HA synthesis or reach tissues, supporting hydration and joint lubrication.
What the evidence shows
Small trials suggest improved skin moisture/elasticity and modest knee-osteoarthritis comfort; mechanisms of oral absorption are debated. Safe, modest.
How to use it
120–240 mg/day.
Safety & interactions
Very safe. Collagen Peptides — Common skin/joint stack.
Bottom line
A low-risk, modest option for skin hydration and knee comfort. Don't expect dramatic effects.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 120–240 mg/day.
Goes with
- Collagen PeptidesCommon skin/joint stack.Evidence grade B
Related reading
Entries that share this one's tags or conditions.
- BoswelliaAn anti-inflammatory resin with some of the better osteoarthritis-pain data among botanicals.Evidence grade B
- GlucosamineA joint mainstay with genuinely divided evidence — modest benefit at best, and a surprising cardiovascular-mortality observational signal in its favor.Evidence grade C
- ChondroitinGlucosamine's usual partner — similarly modest and contested for osteoarthritis.Evidence grade C
- Collagen Peptides for Joint pain / osteoarthritisEvidence grade B — Athletes and OAEvidence grade B
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.