Supplements for menopause

5 compounds relevant to menopause, ranked by overall evidence grade.

Overall grade: Grade B
Last revised: Jul 10, 2026; 5
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade B · 3 at grade C · 1 at grade D — 5 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Soy IsoflavonesPhytoestrogens with real, modest evidence for menopausal hot flashes — and no, they don't feminize men.	Evidence grade B	Unclear	mixed
Black CohoshA menopausal hot-flash botanical with genuinely divided trials and rare liver-safety signals.	Evidence grade C	Unclear	mixed
Red CloverAnother isoflavone source for menopause with weaker, more inconsistent data than soy.	Evidence grade C	Unclear	mixed
Royal JellyThe queen-bee secretion sold for vitality — modest, real signals for lipids and menopausal symptoms amid a lot of hype.	Evidence grade C	Unclear	mixed
Dong QuaiA classic 'female tonic' whose menopause evidence is weak — and it interacts with blood thinners.	Evidence grade D	Unclear	mixed

Soy IsoflavonesEvidence grade B
Phytoestrogens with real, modest evidence for menopausal hot flashes — and no, they don't feminize men.
Unclearmixed
Black CohoshEvidence grade C
A menopausal hot-flash botanical with genuinely divided trials and rare liver-safety signals.
Unclearmixed
Red CloverEvidence grade C
Another isoflavone source for menopause with weaker, more inconsistent data than soy.
Unclearmixed
Royal JellyEvidence grade C
The queen-bee secretion sold for vitality — modest, real signals for lipids and menopausal symptoms amid a lot of hype.
Unclearmixed
Dong QuaiEvidence grade D
A classic 'female tonic' whose menopause evidence is weak — and it interacts with blood thinners.
Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Black Cohosh (grade C); Red Clover (grade C); Royal Jelly (grade C); Dong Quai (grade D).
Studies disagree: Soy Isoflavones (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to menopause, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Soy Isoflavones (B) — Phytoestrogens with real, modest evidence for menopausal hot flashes — and no, they don't feminize men.

Lower-evidence options

Black Cohosh (C) — A menopausal hot-flash botanical with genuinely divided trials and rare liver-safety signals. · Red Clover (C) — Another isoflavone source for menopause with weaker, more inconsistent data than soy. · Royal Jelly (C) — The queen-bee secretion sold for vitality — modest, real signals for lipids and menopausal symptoms amid a lot of hype. · Dong Quai (D) — A classic 'female tonic' whose menopause evidence is weak — and it interacts with blood thinners.

Goes with

Soy IsoflavonesGrade BEvidence grade B
Black CohoshGrade CEvidence grade C
Red CloverGrade CEvidence grade C
Royal JellyGrade CEvidence grade C
Dong QuaiGrade DEvidence grade D

Entries that share this one's tags or conditions.

Black Cohosh for Menopausal hot flashesEvidence grade C — Divided trialsEvidence grade C
Black Cohosh for Menopause symptomsEvidence grade C — InconsistentEvidence grade C
Black Cohosh: dosage and how to take it~40 mg standardized daily.Evidence grade C
Black Cohosh: side effects, safety & interactionsRare hepatotoxicity reports — stop if any liver symptoms; avoid in liver disease.Evidence grade C

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.