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Goal guide · Supplement

Supplements for longevity

13 compounds relevant to longevity, ranked by overall evidence grade.

Overall grade
Grade B
Last revised
13
graded outcomes
0
references listed
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Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade B · 7 at grade C · 5 at grade D — 13 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

  • Rapamycin (Sirolimus)Evidence grade B

    A prescription mTOR inhibitor that extends lifespan in animals like nothing else — and the most serious off-label longevity experiment in humans.

    Unclearmixed

  • NMNEvidence grade C

    An NAD+ precursor with real biomarker effects (NAD+ rises) and no proven clinical or longevity outcomes yet.

    Unclearmixed

  • Nicotinamide RibosideEvidence grade C

    The better-studied NAD+ precursor — reliably raises NAD+, still short on hard human outcomes.

    Unclearmixed

  • QuercetinEvidence grade C

    A flavonoid with modest blood-pressure data, a senolytic research role, and poor absorption to overcome.

    Unclearmixed

  • SpermidineEvidence grade C

    An autophagy-inducing polyamine with intriguing observational and early-trial cognitive signals.

    Unclearmixed

  • Urolithin AEvidence grade C

    A gut-derived metabolite that boosts mitophagy — early human trials show modest muscle-endurance gains.

    Unclearmixed

  • SulforaphaneEvidence grade C

    A broccoli-sprout compound that switches on the body's own antioxidant defenses — real biomarker effects, early clinical data.

    Unclearmixed

  • ErgothioneineEvidence grade C

    A mushroom-derived antioxidant your body has a dedicated transporter for — a 'longevity vitamin' candidate with association, not proof.

    Unclearmixed

  • ResveratrolEvidence grade D

    The 'red wine molecule' that launched the sirtuin craze — and then failed to reproduce its promise in humans.

    Unclearmixed

  • FisetinEvidence grade D

    A flavonoid senolytic star in mice with essentially no completed human outcome data — trials are ongoing.

    Unclearmixed

  • PQQEvidence grade D

    A 'mitochondrial biogenesis' supplement whose small human trials are unconvincing.

    Unclearmixed

  • Calcium AKGEvidence grade D

    A metabolic intermediate with striking mouse-aging data and almost no human outcome evidence.

    Unclearmixed

  • Fo-Ti (He Shou Wu)Evidence grade D

    A traditional longevity-and-hair tonic with weak evidence and a real liver-toxicity signal.

    Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

  • Thin evidence: NMN (grade C); Nicotinamide Riboside (grade C); Quercetin (grade C); Spermidine (grade C); Urolithin A (grade C); Sulforaphane (grade C); Ergothioneine (grade C); Resveratrol (grade D); Fisetin (grade D); PQQ (grade D); Calcium AKG (grade D); Fo-Ti (He Shou Wu) (grade D).
  • Studies disagree: Rapamycin (Sirolimus) (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to longevity, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Rapamycin (Sirolimus) (B) — A prescription mTOR inhibitor that extends lifespan in animals like nothing else — and the most serious off-label longevity experiment in humans.

Lower-evidence options

NMN (C) — An NAD+ precursor with real biomarker effects (NAD+ rises) and no proven clinical or longevity outcomes yet. · Nicotinamide Riboside (C) — The better-studied NAD+ precursor — reliably raises NAD+, still short on hard human outcomes. · Quercetin (C) — A flavonoid with modest blood-pressure data, a senolytic research role, and poor absorption to overcome. · Spermidine (C) — An autophagy-inducing polyamine with intriguing observational and early-trial cognitive signals. · Urolithin A (C) — A gut-derived metabolite that boosts mitophagy — early human trials show modest muscle-endurance gains. · Sulforaphane (C) — A broccoli-sprout compound that switches on the body's own antioxidant defenses — real biomarker effects, early clinical data. · Ergothioneine (C) — A mushroom-derived antioxidant your body has a dedicated transporter for — a 'longevity vitamin' candidate with association, not proof. · Resveratrol (D) — The 'red wine molecule' that launched the sirtuin craze — and then failed to reproduce its promise in humans. · Fisetin (D) — A flavonoid senolytic star in mice with essentially no completed human outcome data — trials are ongoing. · PQQ (D) — A 'mitochondrial biogenesis' supplement whose small human trials are unconvincing. · Calcium AKG (D) — A metabolic intermediate with striking mouse-aging data and almost no human outcome evidence. · Fo-Ti (He Shou Wu) (D) — A traditional longevity-and-hair tonic with weak evidence and a real liver-toxicity signal.

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Related reading

Entries that share this one's tags or conditions.

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised . A grade is this entry's reading of the evidence, not medical advice.