Calcium AKG

A metabolic intermediate with striking mouse-aging data and almost no human outcome evidence.

A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.

1 at grade D — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Biological aging (humans)One small study	Evidence grade D	Unclear	low

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Alpha-ketoglutarate is a Krebs-cycle intermediate popularized for longevity after rodent lifespan/healthspan studies.

It participates in energy metabolism, epigenetic regulation, and collagen synthesis; the anti-aging mechanism in humans is speculative.

Animal data are eye-catching and one small human study reported biological-age-clock changes, but rigorous human outcome data are absent. Very early.

1–3 g/day in experimental protocols.

Appears safe short-term; long-term unknown.

Promising in mice, essentially untested in humans. Wait for real trials.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Entries that share this one's tags or conditions.

Calcium AKG for Biological aging (humans)Evidence grade D — One small studyEvidence grade D
Calcium AKG: dosage and how to take it1–3 g/day.Evidence grade D
Calcium AKG: side effects, safety & interactionsAppears safe short-term; long-term unknown.Evidence grade D
FisetinA flavonoid senolytic star in mice with essentially no completed human outcome data — trials are ongoing.Evidence grade D

This entry lists no references of its own.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.