Compound or practice · Supplement
Fisetin
A flavonoid senolytic star in mice with essentially no completed human outcome data — trials are ongoing.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Senolytic / healthspan (humans)Evidence grade D
No completed human outcomes
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Senolytic / healthspan (humans) (grade D).
The evidence in words
What it is
Fisetin is a flavonoid (strawberries) that emerged as a leading senolytic candidate in animal studies.
How it works
It appears to clear senescent 'zombie' cells that accumulate with age and drive inflammation.
What the evidence shows
The mouse data are striking; human clinical-outcome data are essentially absent, with trials underway. Enthusiasm is running well ahead of evidence. Safe as a food flavonoid.
How to use it
Experimental; some protocols use intermittent high doses — not established.
Safety & interactions
Food flavonoid, appears safe; human dosing unestablished.
Bottom line
Exciting in mice, unproven in humans. Wait for the trials before betting on it.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Experimental
- Not established.
Related reading
Entries that share this one's tags or conditions.
- Fisetin for Senolytic / healthspan (humans)Evidence grade D — No completed human outcomesEvidence grade D
- Fisetin: dosage and how to take itNot established.Evidence grade D
- Fisetin: side effects, safety & interactionsFood flavonoid, appears safe; human dosing unestablished.Evidence grade D
- QuercetinA flavonoid with modest blood-pressure data, a senolytic research role, and poor absorption to overcome.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.