Evidence brief · Supplement
Vitamin B6 for PMS symptoms
Evidence grade B — Modest benefit
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- PMS symptomsEvidence grade B
Modest benefit
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: PMS symptoms (mixed agreement).
The evidence in words
The verdict
For pms symptoms, Vitamin B6 earns evidence grade B (small effect, mixed consistency) — there is real evidence here. Modest benefit
How it might work
P5P is the coenzyme for transaminases and decarboxylases that build serotonin, dopamine, GABA, and heme, and that clear homocysteine via the transsulfuration pathway. Its neurotransmitter roles underlie its use in nausea and premenstrual symptoms.
How to use it
10–25 mg/day covers supplemental needs; pregnancy nausea protocols use 10–25 mg a few times daily under care. Do not chronically exceed ~100 mg/day without reason.
Safety & cautions
Safe at low doses; chronic megadosing causes peripheral neuropathy that resolves slowly on stopping. Respect the upper limit.
Bottom line
Useful and cheap for pregnancy nausea and PMS at modest doses, and a homocysteine cofactor — but this is the water-soluble vitamin to not megadose, because sustained high intakes damage sensory nerves.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 10–25 mg/day; avoid chronic >100 mg.
Goes with
- Vitamin B6Read the full Vitamin B6 monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Vitamin B6 for HomocysteineEvidence grade B — With folate/B12Evidence grade B
- Vitamin B6 for Pregnancy nauseaEvidence grade B — Often with doxylamineEvidence grade B
- Vitamin B6: dosage and how to take it10–25 mg/day; avoid chronic >100 mg.Evidence grade B
- Vitamin B6: side effects, safety & interactionsSafe at low doses; chronic megadosing causes peripheral neuropathy that resolves slowly on stopping. Respect the upper lEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.