Evidence brief · Supplement
Vitamin B6 for Homocysteine
Evidence grade B — With folate/B12
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- HomocysteineEvidence grade B
With folate/B12
Smallhigh
The evidence in words
The verdict
For homocysteine, Vitamin B6 earns evidence grade B (small effect, high consistency) — there is real evidence here. With folate/B12
How it might work
P5P is the coenzyme for transaminases and decarboxylases that build serotonin, dopamine, GABA, and heme, and that clear homocysteine via the transsulfuration pathway. Its neurotransmitter roles underlie its use in nausea and premenstrual symptoms.
How to use it
10–25 mg/day covers supplemental needs; pregnancy nausea protocols use 10–25 mg a few times daily under care. Do not chronically exceed ~100 mg/day without reason.
Safety & cautions
Safe at low doses; chronic megadosing causes peripheral neuropathy that resolves slowly on stopping. Respect the upper limit.
Bottom line
Useful and cheap for pregnancy nausea and PMS at modest doses, and a homocysteine cofactor — but this is the water-soluble vitamin to not megadose, because sustained high intakes damage sensory nerves.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 10–25 mg/day; avoid chronic >100 mg.
Goes with
- Vitamin B6Read the full Vitamin B6 monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Vitamin B6 for PMS symptomsEvidence grade B — Modest benefitEvidence grade B
- Vitamin B6 for Pregnancy nauseaEvidence grade B — Often with doxylamineEvidence grade B
- Folate (B9) for Cardiovascular eventsEvidence grade D — Homocysteine lowering did not cut eventsEvidence grade D
- Folate (B9) for Homocysteine loweringEvidence grade A — Reliable biomarker effectEvidence grade A
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.