Evidence brief · Supplement
Sarcosine for Schizophrenia (adjunct)
Evidence grade B — Add-on
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Schizophrenia (adjunct)Evidence grade B
Add-on
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Schizophrenia (adjunct) (mixed agreement).
The evidence in words
The verdict
For schizophrenia (adjunct), Sarcosine earns evidence grade B (small effect, mixed consistency) — there is real evidence here. Add-on
How it might work
It inhibits the glycine transporter (GlyT1), raising synaptic glycine and boosting NMDA-receptor function — the opposite of ketamine's NMDA blockade.
How to use it
Safety & cautions
Generally well tolerated; should not replace prescribed treatment, and NMDA modulation warrants clinical oversight in psychiatric illness.
Bottom line
A mechanistically interesting NMDA-enhancing amino acid with real (if small) adjunct evidence in schizophrenia — a clinical adjunct, not a casual nootropic.
Goes with
- SarcosineRead the full Sarcosine monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Sarcosine for OCD / depressionEvidence grade C — PreliminaryEvidence grade C
- Sarcosine: side effects, safety & interactionsGenerally well tolerated; should not replace prescribed treatment, and NMDA modulation warrants clinical oversight in psEvidence grade C
- Acetyl-L-Carnitine (ALCAR) for Cognition (MCI/aging)Evidence grade C — ModestEvidence grade C
- Acetyl-L-Carnitine (ALCAR) for Depression (older adults)Evidence grade B — AdjunctEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.