Evidence brief · Supplement
Pregnenolone for Memory / mood
Evidence grade D — Weak, old
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Memory / moodEvidence grade D
Weak, old
Triviallow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Memory / mood (grade D).
The evidence in words
The verdict
For memory / mood, Pregnenolone earns evidence grade D (trivial effect, low consistency) — the evidence does not support the claim. Weak, old
How it might work
It converts into DHEA, progesterone, cortisol, and sex hormones, and acts as a neurosteroid.
How to use it
Safety & cautions
Unpredictable hormonal effects; not for casual use; banned in some sport contexts.
Bottom line
A hormone precursor with thin evidence and unpredictable downstream effects. Not a supplement to self-prescribe.
Goes with
- PregnenoloneRead the full Pregnenolone monographEvidence grade D
Related reading
Entries that share this one's tags or conditions.
- DHEA for Deficiency (adrenal insufficiency)Evidence grade B — Under careEvidence grade B
- DHEA for Wellbeing (healthy young)Evidence grade D — Little benefit, real riskEvidence grade D
- Pregnenolone: side effects, safety & interactionsUnpredictable hormonal effects; not for casual use; banned in some sport contexts.Evidence grade D
- Centrophenoxine for Cognition (elderly)Evidence grade D — DatedEvidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.