Evidence brief · Supplement
Choline for Fetal brain development (pregnancy)
Evidence grade B — Adequacy matters
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Fetal brain development (pregnancy)Evidence grade B
Adequacy matters
Moderatemixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Fetal brain development (pregnancy) (mixed agreement).
The evidence in words
The verdict
For fetal brain development (pregnancy), Choline earns evidence grade B (moderate effect, mixed consistency) — there is real evidence here. Adequacy matters
How it might work
It builds phosphatidylcholine and acetylcholine and donates methyl groups; the liver and brain are especially choline-dependent.
How to use it
Meet the adequate intake (~425–550 mg/day) from eggs, meat, and soy; prenatal supplementation is often inadequate in choline.
Safety & cautions
High doses cause fishy odor and GI effects; very high intakes may raise TMAO.
Bottom line
An overlooked essential — prioritize adequacy, especially in pregnancy. Eggs are the easiest source; most prenatals skimp on it.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Adequacy
- 425–550 mg/day; more in pregnancy.
Goes with
- CholineRead the full Choline monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Choline for Cognition (replete adults)Evidence grade C — WeakEvidence grade C
- Choline for Liver fatEvidence grade C — Deficiency raises riskEvidence grade C
- Choline for Pregnancy (fetal development)Evidence grade B — AdequacyEvidence grade B
- Choline: dosage and how to take it425–550 mg/day; more in pregnancy.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.