Choline for Cognition (replete adults)

Evidence grade C — Weak

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade C — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Cognition (replete adults)Weak	Evidence grade C	Small	low

Read off the same rows as above. Nothing here is added that the entry does not itself record.

For cognition (replete adults), Choline earns evidence grade C (small effect, low consistency) — the evidence is limited or mixed. Weak

It builds phosphatidylcholine and acetylcholine and donates methyl groups; the liver and brain are especially choline-dependent.

Meet the adequate intake (~425–550 mg/day) from eggs, meat, and soy; prenatal supplementation is often inadequate in choline.

High doses cause fishy odor and GI effects; very high intakes may raise TMAO.

An overlooked essential — prioritize adequacy, especially in pregnancy. Eggs are the easiest source; most prenatals skimp on it.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Entries that share this one's tags or conditions.

Choline for Fetal brain development (pregnancy)Evidence grade B — Adequacy mattersEvidence grade B
Choline for Liver fatEvidence grade C — Deficiency raises riskEvidence grade C
Choline for Pregnancy (fetal development)Evidence grade B — AdequacyEvidence grade B
Choline: dosage and how to take it425–550 mg/day; more in pregnancy.Evidence grade B

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.