Dosage · Supplement
Thiamine (B1): dosage and how to take it
Higher oral doses in alcohol-use disorder / post-bariatric; parenteral for acute deficiency.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
How much to take
Requirement is ~1–1.5 mg/day. At-risk groups (heavy drinkers, post-bariatric) use higher oral doses or, in acute deficiency, parenteral thiamine under care.
Timing & separation
There are no strict timing conflicts on record for Thiamine (B1); consistency matters more than the exact hour for most goals.
Why the dose is what it is
As thiamine pyrophosphate it is a cofactor for pyruvate dehydrogenase and transketolase — nodes where carbohydrate metabolism feeds the energy and pentose-phosphate pathways. Nervous tissue, heavily glucose-dependent, fails first when it runs out.
Bottom line
A quiet essential with a dramatic deficiency. Most people get enough; heavy drinkers, the malnourished, and bariatric-surgery patients should supplement — and acute deficiency is an ER matter, not a capsule.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- At-risk
- Higher oral doses in alcohol-use disorder / post-bariatric; parenteral for acute deficiency.
Goes with
- Thiamine (B1)Full Thiamine (B1) monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Iodine: dosage and how to take itIodized salt / seafood; ~150 µg in pregnancy prenatals.Evidence grade B
- Thiamine (B1) for Deficiency syndromesEvidence grade A — Beriberi, Wernicke'sEvidence grade A
- Thiamine (B1) for Diabetic neuropathy (benfotiamine)Evidence grade B — Modest symptom reliefEvidence grade B
- Thiamine (B1): side effects, safety & interactionsVery safe; excess is excreted. The risk is missing deficiency, not the supplement.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.