Dosage · Supplement
Niacin (B3): dosage and how to take it
500 mg twice daily in high-risk patients, under care.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
How much to take
Requirement is milligrams from food. Pharmacologic niacin for lipids is largely abandoned and should only ever be used under a clinician. Nicotinamide 500 mg twice daily is the skin-cancer-prevention protocol in high-risk patients.
Timing & separation
There are no strict timing conflicts on record for Niacin (B3); consistency matters more than the exact hour for most goals.
Why the dose is what it is
As NAD/NADP it participates in hundreds of reactions. At gram doses nicotinic acid inhibits hepatic VLDL/triglyceride production and raises HDL — an impressive lipid-panel effect that, unusually, did not translate into fewer cardiovascular events.
Bottom line
You need milligrams to avoid deficiency and get them from food. The high-dose 'raise your HDL' era is over — it improved the panel without improving outcomes. Leave pharmacologic niacin to physicians.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Skin (nicotinamide)
- 500 mg twice daily in high-risk patients, under care.
Goes with
- Niacin (B3)Full Niacin (B3) monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Aloe Vera: dosage and how to take itGel for minor burns.Evidence grade C
- Astaxanthin: dosage and how to take it4–12 mg/day with fat.Evidence grade C
- Biotin (B7): dosage and how to take itPer clinician; stop before blood tests.Evidence grade C
- Collagen Peptides: dosage and how to take it10–15 g with 50 mg vitamin C, 30–60 min pre-load.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.