Compound or practice · Supplement
Agmatine
An arginine metabolite popular in pre-workouts with almost no human performance evidence.
- Overall grade
- Grade D
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C · 1 at grade D — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Neuropathic painEvidence grade C
One small study
Smalllow
- Exercise performanceEvidence grade D
No real human data
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Neuropathic pain (grade C); Exercise performance (grade D).
The evidence in words
What it is
Agmatine is a metabolite of arginine marketed for pumps, mood, and neuropathic pain.
How it works
It modulates nitric-oxide synthase and several receptors (NMDA, imidazoline); human relevance is unestablished.
What the evidence shows
Human data are scarce; a small study suggests neuropathic-pain benefit, but ergogenic and mood claims rest on preclinical work. Largely speculative as a supplement.
How to use it
500–1,000 mg pre-workout if trialing; evidence is thin.
Safety & interactions
Limited human safety data; generally tolerated short-term.
Bottom line
Trendy in pre-workouts, thin on human evidence. Skip for proven ingredients.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- If trialing
- 500–1,000 mg pre-workout.
Related reading
Entries that share this one's tags or conditions.
- Agmatine for Exercise performanceEvidence grade D — No real human dataEvidence grade D
- Agmatine for Neuropathic painEvidence grade C — One small studyEvidence grade C
- Agmatine: dosage and how to take it500–1,000 mg pre-workout.Evidence grade D
- Agmatine: side effects, safety & interactionsLimited human safety data; generally tolerated short-term.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.