Compound or practice · Supplement
Uridine
A nucleotide with a plausible membrane-and-dopamine story and thin standalone human data.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Cognition (with DHA/choline)Evidence grade C
Combination data
Smalllow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Cognition (with DHA/choline) (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
CholineWorks together
Membrane-synthesis stack, often with DHA.
The evidence in words
What it is
Uridine (as UMP) is a pyrimidine nucleotide involved in synaptic membrane synthesis, marketed for mood and cognition.
How it works
It supports phosphatidylcholine synthesis for neuronal membranes and may enhance dopamine signaling; often stacked with choline and DHA.
What the evidence shows
The strongest data are for a uridine + DHA + choline combination in age-related cognitive decline; standalone uridine evidence in healthy people is limited. Mechanistically coherent, clinically preliminary.
Safety & interactions
Generally tolerated. Choline — Membrane-synthesis stack, often with DHA.
Bottom line
Interesting as part of a membrane-support stack with DHA and choline; weak on its own. Preliminary.
Goes with
- CholineMembrane-synthesis stack, often with DHA.Evidence grade B
Related reading
Entries that share this one's tags or conditions.
- Uridine for Cognition (with DHA/choline)Evidence grade C — Combination dataEvidence grade C
- Uridine: side effects, safety & interactionsGenerally tolerated.Evidence grade C
- Acetyl-L-Carnitine (ALCAR)The brain-penetrant carnitine — real evidence for diabetic neuropathy, softer signals for mood and aging cognition.Evidence grade B
- AniracetamA fat-soluble racetam with an anxiety-and-mood reputation and mostly preclinical human backing.Evidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.