Safety · Supplement
Vitamin E: side effects, safety & interactions
High doses thin the blood and raise bleeding risk, compounding anticoagulants and antiplatelets; meta-analyses link ≥400
- Overall grade
- Grade C
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
High doses thin the blood and raise bleeding risk, compounding anticoagulants and antiplatelets; meta-analyses link ≥400 IU/day to slightly higher mortality.
Interactions to respect
Anticoagulants (warfarin) — High-dose E adds bleeding risk on anticoagulants.
What Vitamin E is
Vitamin E is a family of fat-soluble antioxidants (tocopherols and tocotrienols); alpha-tocopherol is the main circulating form. Dietary deficiency is rare outside fat-malabsorption disorders.
The honest bottom line
Skip the high-dose antioxidant capsules. Eat nuts and seeds. Reserve therapeutic doses for specific medical indications under care.
Related reading
Entries that share this one's tags or conditions.
- Glutathione: side effects, safety & interactionsWell tolerated; skin-lightening IV use is a separate, unregulated concern.Evidence grade C
- Milk Thistle (Silymarin): side effects, safety & interactionsVery safe; occasional GI upset. Not a substitute for medical care in liver disease.Evidence grade C
- Astaxanthin: side effects, safety & interactionsSafe; harmless slight skin-tone change at high doses.Evidence grade C
- Chaga: side effects, safety & interactionsOxalate load — kidney-stone/injury risk; caution with anticoagulants and diabetes drugs.Evidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.