Safety · Supplement
SAM-e: side effects, safety & interactions
Can cause anxiety/insomnia and, being serotonergic, must not be combined with antidepressants without a prescriber; caut
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
The evidence in words
Safety profile
Can cause anxiety/insomnia and, being serotonergic, must not be combined with antidepressants without a prescriber; caution in bipolar disorder.
Interactions to respect
SSRIs / SNRIs — Serotonergic — serotonin-syndrome risk; only with a prescriber.
What SAM-e is
S-adenosylmethionine (SAM-e) is the body's universal methyl donor, sold for depression and joint pain.
The honest bottom line
One of the better-evidenced natural antidepressants and a real OA option — but expensive and serotonergic. Never stack with antidepressants unsupervised.
Related reading
Entries that share this one's tags or conditions.
- SAM-e for DepressionEvidence grade B — Incl. add-onEvidence grade B
- Curcumin (Turmeric): side effects, safety & interactionsWell tolerated; high doses can cause GI upset. It has mild antiplatelet action (additive with anticoagulants) and, via pEvidence grade B
- Saffron: side effects, safety & interactionsWell tolerated at supplemental doses; culinary-scale amounts are safe, but very high doses are toxic. As a serotonergic Evidence grade B
- SAM-eA methyl donor with genuine antidepressant and osteoarthritis evidence — effective, pricey, and serotonergic.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.