Compound or practice · Supplement
Pramiracetam
A potent racetam with intriguing older memory data but thin, dated human evidence.
- Overall grade
- Grade D
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade D — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Memory / cognitionEvidence grade D
Old, small studies
Unclearlow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Memory / cognition (grade D).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
Alpha-GPCWorks together
Racetams work better with a choline source; reduces headaches.
The evidence in words
What it is
Pramiracetam is a fat-soluble racetam, more potent by weight than piracetam, used off-label for memory and focus.
How it works
It enhances high-affinity choline uptake in the hippocampus and modulates glutamatergic signaling; a strong choline supply is usually recommended alongside.
What the evidence shows
A handful of small, older studies (including in traumatic brain injury and age-related memory decline) reported cognitive benefits, but modern, well-controlled trials in healthy people are essentially absent. Promising anecdotally, unproven rigorously.
Safety & interactions
Generally tolerated (headache — often choline-responsive); long-term data limited; unapproved as a drug in most countries. Alpha-GPC — Racetams work better with a choline source; reduces headaches.
Bottom line
A potent racetam with old, limited positive data and little modern evidence. Experimental; pair with choline if used.
Goes with
- Alpha-GPCRacetams work better with a choline source; reduces headaches.Evidence grade C
Related reading
Entries that share this one's tags or conditions.
- Bacopa MonnieriThe nootropic that actually improves memory — but slowly, over 8–12 weeks, not on the day you take it.Evidence grade B
- Citicoline (CDP-Choline)A choline source with modest attention and memory data — the more evidence-backed of the popular cholinergics.Evidence grade C
- Pramiracetam for Memory / cognitionEvidence grade D — Old, small studiesEvidence grade D
- Pramiracetam: side effects, safety & interactionsGenerally tolerated (headache — often choline-responsive); long-term data limited; unapproved as a drug in most countrieEvidence grade D
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.