Compound or practice · Supplement
Phosphatidic Acid
An mTOR-signaling lipid with a couple of small muscle-growth studies — promising mechanism, thin evidence.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Lean mass / strengthEvidence grade C
Few small trials
Smalllow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Lean mass / strength (grade C).
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
CreatineWorks together
Complementary muscle-growth mechanisms.
The evidence in words
What it is
Phosphatidic acid is a phospholipid signaling molecule marketed to enhance resistance-training muscle growth.
How it works
It activates mTOR, the central regulator of muscle-protein synthesis, in response to mechanical load.
What the evidence shows
A few small, sometimes industry-linked trials show modest gains in lean mass and strength at 750 mg/day with training; independent replication is limited. Mechanistically appealing, evidentially thin.
How to use it
750 mg/day (often split), around training.
Safety & interactions
Appears safe; limited long-term data. Creatine — Complementary muscle-growth mechanisms.
Bottom line
A plausible muscle-growth aid with only a few supporting studies. Modest at best; not a priority over protein and creatine.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 750 mg/day with training.
Goes with
- CreatineComplementary muscle-growth mechanisms.Evidence grade A
Related reading
Entries that share this one's tags or conditions.
- EcdysteroneAn insect/plant steroid with one surprisingly positive muscle trial — interesting, under-replicated, and dose-uncertain.Evidence grade C
- Phosphatidic Acid for Lean mass / strengthEvidence grade C — Few small trialsEvidence grade C
- Phosphatidic Acid: dosage and how to take it750 mg/day with training.Evidence grade C
- Phosphatidic Acid: side effects, safety & interactionsAppears safe; limited long-term data.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.