Compound or practice · Supplement
MSM
A sulfur donor with small joint-pain and exercise-recovery signals, often bundled into joint formulas.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
2 at grade C — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Osteoarthritis painEvidence grade C
Modest
Smallmixed
- Exercise sorenessEvidence grade C
Reduced markers
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Osteoarthritis pain (grade C); Exercise soreness (grade C).
The evidence in words
What it is
MSM (methylsulfonylmethane) is an organic sulfur compound used for joint pain and recovery.
How it works
It supplies sulfur for connective tissue and has antioxidant/anti-inflammatory activity.
What the evidence shows
Small trials show modest reductions in osteoarthritis pain and in exercise-induced muscle soreness and oxidative markers. Evidence is limited and often in blends; it is safe and cheap.
How to use it
1.5–3 g/day, alone or in joint/recovery formulas.
Safety & interactions
Well tolerated; mild GI effects.
Bottom line
A cheap, safe, modest add-on for joint pain and recovery. Fine in a stack; not a standout on its own.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 1.5–3 g/day.
Related reading
Entries that share this one's tags or conditions.
- MSM for Exercise sorenessEvidence grade C — Reduced markersEvidence grade C
- MSM for Osteoarthritis painEvidence grade C — ModestEvidence grade C
- MSM: dosage and how to take it1.5–3 g/day.Evidence grade C
- MSM: side effects, safety & interactionsWell tolerated; mild GI effects.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.