MSM for Osteoarthritis pain

Evidence grade C — Modest

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade C — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Osteoarthritis painModest	Evidence grade C	Small	mixed

Read off the same rows as above. Nothing here is added that the entry does not itself record.

For osteoarthritis pain, MSM earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Modest

It supplies sulfur for connective tissue and has antioxidant/anti-inflammatory activity.

1.5–3 g/day, alone or in joint/recovery formulas.

Well tolerated; mild GI effects.

A cheap, safe, modest add-on for joint pain and recovery. Fine in a stack; not a standout on its own.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Entries that share this one's tags or conditions.

MSM for Exercise sorenessEvidence grade C — Reduced markersEvidence grade C
Curcumin (Turmeric) for Osteoarthritis painEvidence grade B — NSAID-comparable in trialsEvidence grade B
Glucosamine for Osteoarthritis painEvidence grade C — Split trialsEvidence grade C
MSM: dosage and how to take it1.5–3 g/day.Evidence grade C

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.