Compound or practice · Supplement
Magnolia Bark
A traditional anti-stress bark (honokiol/magnolol) with early cortisol and sleep signals.
- Overall grade
- Grade C
- Last revised
- 2
- graded outcomes
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
2 at grade C — 2 graded rows
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Stress / cortisolEvidence grade C
Often combined
Smallmixed
- SleepEvidence grade C
Early
Smalllow
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Stress / cortisol (grade C); Sleep (grade C).
- Caution with Benzodiazepines: Additive sedation.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
BenzodiazepinesCaution
Additive sedation.
The evidence in words
What it is
Magnolia bark supplies honokiol and magnolol, used for stress, cortisol, and sleep.
How it works
GABAergic and cortisol-modulating actions; honokiol has anxiolytic activity in models.
What the evidence shows
Small studies (often combined with phellodendron) suggest reduced stress/cortisol and improved sleep and, in menopause blends, symptom relief. Evidence is limited but coherent. Safe short-term.
How to use it
Standardized honokiol/magnolol extract, evening for sleep.
Safety & interactions
Generally safe short-term; additive sedation. benzodiazepines — Additive sedation.
Bottom line
An early-evidence anti-stress and sleep botanical. Reasonable low-risk trial, often in blends.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- Standardized extract, evening.
Related reading
Entries that share this one's tags or conditions.
- Magnolia Bark for SleepEvidence grade C — EarlyEvidence grade C
- KavaOne of the few genuinely effective anxiety botanicals — shadowed by a real (if debated) liver-safety history.Evidence grade B
- Lemon BalmA pleasant mint-family herb with small acute anxiety, mood, and sleep signals.Evidence grade C
- Magnolia Bark for Stress / cortisolEvidence grade C — Often combinedEvidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.