Interaction · Supplement
Synephrine + Caffeine: use with caution
Additive cardiovascular stimulation in fat-burner stacks.
- Overall grade
- Grade B
- Last revised
- 0
- graded outcomes
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Watch with Synephrine: About Synephrine
- Watch with Caffeine: About Caffeine
The evidence in words
The interaction
Synephrine and Caffeine — a caution interaction. Additive cardiovascular stimulation in fat-burner stacks.
What to do
Do not combine these casually. The interaction can matter clinically — bring it to the prescriber who manages the medication before stacking them.
About Synephrine
Synephrine is a stimulant alkaloid from bitter orange (Citrus aurantium), common in fat-burner formulas.
The bigger picture
Supplement–drug and supplement–supplement interactions are the reason a stack should be read as a system, not a list. This platform's interactions graph maps them; the medication side always belongs with the person who prescribes it.
Related reading
Entries that share this one's tags or conditions.
- Caffeine + ADHD stimulants: use with cautionAdditive stimulation and cardiovascular strain on top of prescription stimulants.Evidence grade B
- Guarana + Caffeine: use with cautionIt IS caffeine — don't double up.Evidence grade B
- Rhodiola Rosea + Caffeine: use with cautionBoth activating — stack low-dose or trade calm focus for edge.Evidence grade B
- Alcohol + Benzodiazepines: use with cautionAdditive CNS and respiratory depression — a leading cause of sedative overdose.Evidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.