Compound or practice · Supplement
Gynostemma (Jiaogulan)
An AMPK-activating adaptogen tea with early metabolic and stress signals.
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
A structured monograph in Prometheus's bundled library. Its grades are the monograph's own reading of the evidence, not a peer-reviewed review.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Metabolic markersEvidence grade C
Small trials
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Metabolic markers (grade C).
- Caution with Metformin: Additive glucose lowering.
Interactions
Documented pairings with supplements and medicines. A medicine on this list is a conversation for whoever prescribes it.
MetforminCaution
Additive glucose lowering.
The evidence in words
What it is
Gynostemma pentaphyllum (jiaogulan) is an adaptogenic herb containing ginseng-like gypenosides.
How it works
Gypenosides activate AMPK (like berberine) and have adaptogenic, antioxidant activity.
What the evidence shows
Small trials suggest improvements in metabolic markers (glucose, lipids, weight) and stress; evidence is limited but coherent. A promising, safe adaptogen.
Safety & interactions
Generally safe; possible additive glucose lowering. metformin — Additive glucose lowering.
Bottom line
An AMPK-activating adaptogen with early metabolic promise. Low-risk; evidence still thin.
Related reading
Entries that share this one's tags or conditions.
- Green Tea Extract (EGCG)Modest metabolic and cardiovascular benefits from catechins — and a real, if uncommon, liver-toxicity signal at high concentrated doses.Evidence grade C
- Gynostemma (Jiaogulan) for Metabolic markersEvidence grade C — Small trialsEvidence grade C
- Gynostemma (Jiaogulan): side effects, safety & interactionsGenerally safe; possible additive glucose lowering.Evidence grade C
- American GinsengDistinct from Asian ginseng — its best data are for glucose control and reducing cold frequency.Evidence grade C
Sources
This entry lists no references of its own.
Last revised . A grade is this entry's reading of the evidence, not medical advice.