Supplements for bone health

7 compounds relevant to bone health, ranked by overall evidence grade.

Overall grade: Grade A
Last revised: Jul 10, 2026; 7
graded outcomes: 0
references listed

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade A · 3 at grade B · 3 at grade C — 7 graded rows

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
Vitamin DA steroid hormone precursor that most temperate-latitude adults run low on — worth correcting, oversold as a cure-all.	Evidence grade A	Unclear	mixed
Vitamin K2The traffic cop for calcium — activates proteins that steer it into bone and away from arteries.	Evidence grade B	Unclear	mixed
CalciumFood-first for bone; the supplement matters mainly when dairy is out — and megadosing may not be free of cardiovascular cost.	Evidence grade B	Unclear	mixed
PhosphorusAn essential mineral you almost never need to supplement — deficiency is rare, and excess (from additives) is the real modern problem.	Evidence grade B	Unclear	mixed
SiliconA trace element with modest bone and hair/skin/nail signals via collagen support.	Evidence grade C	Unclear	mixed
Cissus QuadrangularisAn Ayurvedic bone-and-joint herb with early evidence for fracture healing and joint pain.	Evidence grade C	Unclear	mixed
StrontiumA bone-density mineral where the prescription form worked but raised cardiovascular risk — the OTC citrate is a different, unproven story.	Evidence grade C	Unclear	mixed

Vitamin DEvidence grade A
A steroid hormone precursor that most temperate-latitude adults run low on — worth correcting, oversold as a cure-all.
Unclearmixed
Vitamin K2Evidence grade B
The traffic cop for calcium — activates proteins that steer it into bone and away from arteries.
Unclearmixed
CalciumEvidence grade B
Food-first for bone; the supplement matters mainly when dairy is out — and megadosing may not be free of cardiovascular cost.
Unclearmixed
PhosphorusEvidence grade B
An essential mineral you almost never need to supplement — deficiency is rare, and excess (from additives) is the real modern problem.
Unclearmixed
SiliconEvidence grade C
A trace element with modest bone and hair/skin/nail signals via collagen support.
Unclearmixed
Cissus QuadrangularisEvidence grade C
An Ayurvedic bone-and-joint herb with early evidence for fracture healing and joint pain.
Unclearmixed
StrontiumEvidence grade C
A bone-density mineral where the prescription form worked but raised cardiovascular risk — the OTC citrate is a different, unproven story.
Unclearmixed

What is uncertain

Read off the same rows as above. Nothing here is added that the entry does not itself record.

Thin evidence: Silicon (grade C); Cissus Quadrangularis (grade C); Strontium (grade C).
Studies disagree: Vitamin D (mixed agreement); Vitamin K2 (mixed agreement); Calcium (mixed agreement); Phosphorus (mixed agreement).

The evidence in words

The shortlist

Every compound in the knowledge base tagged to bone health, ordered by how strong its overall evidence is. Start at the top; the grade is the honest filter.

Worth considering first

Vitamin D (A) — A steroid hormone precursor that most temperate-latitude adults run low on — worth correcting, oversold as a cure-all. · Vitamin K2 (B) — The traffic cop for calcium — activates proteins that steer it into bone and away from arteries. · Calcium (B) — Food-first for bone; the supplement matters mainly when dairy is out — and megadosing may not be free of cardiovascular cost. · Phosphorus (B) — An essential mineral you almost never need to supplement — deficiency is rare, and excess (from additives) is the real modern problem.

Lower-evidence options

Silicon (C) — A trace element with modest bone and hair/skin/nail signals via collagen support. · Cissus Quadrangularis (C) — An Ayurvedic bone-and-joint herb with early evidence for fracture healing and joint pain. · Strontium (C) — A bone-density mineral where the prescription form worked but raised cardiovascular risk — the OTC citrate is a different, unproven story.

Goes with

Vitamin DGrade AEvidence grade A
Vitamin K2Grade BEvidence grade B
CalciumGrade BEvidence grade B
PhosphorusGrade BEvidence grade B
SiliconGrade CEvidence grade C
Cissus QuadrangularisGrade CEvidence grade C
StrontiumGrade CEvidence grade C

Entries that share this one's tags or conditions.

Calcium for Cardiovascular risk (supplements)Evidence grade C — Debated small increaseEvidence grade C
Calcium for Fracture risk (with D, deficient)Evidence grade B — In the under-suppliedEvidence grade B
Calcium: dosage and how to take it≤500 mg per dose, with D and K2; citrate needs no acid.Evidence grade B
Calcium: side effects, safety & interactionsConstipation and, at high supplemental doses, kidney-stone and possibly cardiovascular concerns. Prefer dietary calcium Evidence grade B

Sources

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.