Evidence brief · Supplement
Synephrine for Metabolic rate / fat loss
Evidence grade C — Usually with caffeine
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Metabolic rate / fat lossEvidence grade C
Usually with caffeine
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Metabolic rate / fat loss (grade C).
The evidence in words
The verdict
For metabolic rate / fat loss, Synephrine earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Usually with caffeine
How it might work
It has mild adrenergic (fat-mobilizing, thermogenic) activity, weaker than ephedrine.
How to use it
Safety & cautions
Raises heart rate/blood pressure; caution with stimulants, heart conditions, and before exercise.
Bottom line
A mild thermogenic with a real stimulant footprint. Modest at best; treat stacked fat-burners with caution.
Goes with
- SynephrineRead the full Synephrine monographEvidence grade C
Related reading
Entries that share this one's tags or conditions.
- Capsaicin / Capsimax for Energy expenditure / fat oxidationEvidence grade C — MinorEvidence grade C
- Capsaicin / Capsimax for Neuropathic / OA pain (topical)Evidence grade B — EstablishedEvidence grade B
- CLA (Conjugated Linoleic Acid) for Fat lossEvidence grade D — Not meaningfulEvidence grade D
- Forskolin for Fat lossEvidence grade D — Weak, unreplicatedEvidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.