Evidence brief · Supplement
CLA (Conjugated Linoleic Acid) for Insulin sensitivity
Evidence grade C — Possible worsening
- Overall grade
- Grade C
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade C — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Insulin sensitivityEvidence grade C
Possible worsening
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Thin evidence: Insulin sensitivity (grade C).
The evidence in words
The verdict
For insulin sensitivity, CLA (Conjugated Linoleic Acid) earns evidence grade C (small effect, mixed consistency) — the evidence is limited or mixed. Possible worsening
How it might work
Certain isomers alter fat metabolism in animals dramatically; humans respond far less, and the synthetic isomer mix differs from the natural one.
How to use it
Not recommended for fat loss.
Safety & cautions
High-dose synthetic CLA may adversely affect metabolic markers.
Bottom line
Skip it. The fat-loss effect is negligible in humans and the synthetic isomers may do metabolic harm.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- n/a
- Not recommended.
Goes with
- CLA (Conjugated Linoleic Acid)Read the full CLA (Conjugated Linoleic Acid) monographEvidence grade D
Related reading
Entries that share this one's tags or conditions.
- CLA (Conjugated Linoleic Acid) for Fat lossEvidence grade D — Not meaningfulEvidence grade D
- Forskolin for Fat lossEvidence grade D — Weak, unreplicatedEvidence grade D
- Chromium for Body weightEvidence grade D — Not clinically meaningfulEvidence grade D
- Chromium for Glycemic controlEvidence grade D — Inconsistent, tinyEvidence grade D
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.