Betaine (TMG) for Homocysteine

Evidence grade B — Reliable biomarker drop

Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.

1 at grade B — 1 graded row

What is known

Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.

Outcome	Grade	Effect size	Agreement
HomocysteineReliable biomarker drop	Evidence grade B	Moderate	high

For homocysteine, Betaine (TMG) earns evidence grade B (moderate effect, high consistency) — there is real evidence here. Reliable biomarker drop

As an osmolyte it supports cell hydration and possibly creatine synthesis; as a methyl donor it converts homocysteine to methionine.

2.5 g/day, often split, alongside training.

Well tolerated; can raise LDL/triglycerides slightly at high doses.

A cheap maybe-ergogenic. 2.5 g/day for a small shot at better power/composition; also lowers homocysteine.

As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.

Entries that share this one's tags or conditions.

Betaine (TMG) for Power / body compositionEvidence grade C — 2.5 g/dayEvidence grade C
Betaine (TMG): dosage and how to take it2.5 g/day, split.Evidence grade C
Betaine (TMG): side effects, safety & interactionsWell tolerated; can raise LDL/triglycerides slightly at high doses.Evidence grade C
DMG (Dimethylglycine) for Endurance / immunityEvidence grade D — UnsupportedEvidence grade D

This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.

Last revised Jul 10, 2026. A grade is this entry's reading of the evidence, not medical advice.