Evidence brief · Supplement
Alpha-Lipoic Acid for Insulin sensitivity / glucose
Evidence grade B — Modest
- Overall grade
- Grade B
- Last revised
- 1
- graded outcome
- 0
- references listed
Assembled by the app from other entries in this library. It adds no evidence of its own — follow the links to the entries it draws on.
1 at grade B — 1 graded row
What is known
Each outcome with its grade (how strong the evidence is, A to D), the size of the effect where the entry records one, and how often studies agree.
- Insulin sensitivity / glucoseEvidence grade B
Modest
Smallmixed
What is uncertain
Read off the same rows as above. Nothing here is added that the entry does not itself record.
- Studies disagree: Insulin sensitivity / glucose (mixed agreement).
The evidence in words
The verdict
For insulin sensitivity / glucose, Alpha-Lipoic Acid earns evidence grade B (small effect, mixed consistency) — there is real evidence here. Modest
How it might work
It regenerates other antioxidants and improves insulin signaling and nerve microcirculation, the basis for its neuropathy use.
How to use it
300–600 mg/day (R-ALA is the active isomer); take on an empty stomach for absorption.
Safety & cautions
Generally safe; can lower glucose (watch for lows with diabetes meds) and rarely triggers an insulin-autoimmune reaction.
Bottom line
A legitimate option for diabetic neuropathy symptoms and mild glucose improvement. 300–600 mg/day; coordinate with any diabetes medication.
How it is used
As the entry records it, from the studies it summarises. Not a recommendation for you — doses that suit a trial population may not suit you.
- Standard
- 300–600 mg/day, empty stomach.
Goes with
- Alpha-Lipoic AcidRead the full Alpha-Lipoic Acid monographEvidence grade B
Related reading
Entries that share this one's tags or conditions.
- Alpha-Lipoic Acid for Diabetic neuropathyEvidence grade B — Symptom reliefEvidence grade B
- Alpha-Lipoic Acid for Diabetic neuropathy symptomsEvidence grade B — Including IV dataEvidence grade B
- Alpha-Lipoic Acid: dosage and how to take it300–600 mg/day, empty stomach.Evidence grade B
- Alpha-Lipoic Acid: side effects, safety & interactionsGenerally safe; can lower glucose (watch for lows with diabetes meds) and rarely triggers an insulin-autoimmune reactionEvidence grade B
Sources
This entry lists no references of its own — it is assembled from the entries it links to, whose sources are on their pages.
Last revised . A grade is this entry's reading of the evidence, not medical advice.